100th CME Webinar

Event Details Date: 23rd June2023 Time: 3:00 PM To 5:00 PM Venue: Online CME webinar details: Talk 1. HIV IN CHILDREN Speaker: Prof. Dr.Jamaluddin b. Haji Mohamad, Department of Paediatrics, Faculty of Medicine, Bioscience, and Nursing, MAHSA University Time: 3:00 pm - 4:00 pm ABTRACT This talk is about HIV infection in children and the challenges of management of it.There are about 1.8 million of children who are living in HIV. Most of the cases of HIV are in the sub-Saharan region in Africa. In this CME will explain the possible route of transmission, treatment and prevention of this disease in children. Treatment has been challenging in children as it involves complex drug regimes and issue of compliance plus adherence. The management will depend on three components , WHO clinical staging,CD4 count and the viral load. The aim of treatment is to promote normal growth, development and psychological well being .Perinatal transmission will also be discuss and the success of MTCT( maternal -to-child transmission) programme in Malaysia. Talk 2: Epigenetic and Molecular Mechanisms of Diabetes Speaker: Associate Professor Dr Sher Zaman Safi, Department of Biochemistry, Faculty of Medicine, Bioscience, and Nursing, MAHSA University Time: 4:00 pm - 5:00 pm Abstract Malaysia has the highest rate of obesity and diabetes in Western Pacific region and one of the highest in the world. Diabetes mellitus is a multifactorial disease characterized by hyperglycemia and impaired insulin secretion. At the same time, it can also be a polygenic disorder that results from the cumulative effects of several genes. Over the past decade, various international research centers have been established to study and identify the underlying genes which are associated with diabetes and diabetes related complications such as diabetic retinopathy, renal failure, nerve damage, and diabetes-accelerated atherosclerosis. The molecular mechanisms of diabetes are very complex. Hyperglycemia is the root cause of diabetes, but hyperglycemic itself is caused by the implications of various genes including impaired signaling transduction, changes in the expression of target genes, mutations in the transcription factors or cross talk from other hormonal and biochemical systems. All the implicated molecular pathways indicate a single hyperglycaemia-induced process in which a number of genes are epigenetically modified. This epigenetics-regulated and glucose-mediated vascular damage provides a new conceptual framework for future research and drug discovery.