From Aaron Quinlan's course on Applied Computational Genomics at the University of Utah (https://github.com/quinlan-lab/applied-computational-genomics). This lecture introduces the concepts of DNA mapping and its complexities with hash-based mapping strategies. It also introduces the Smith-Waterman alignment algorithm to discern an optimal sequence alignment given a scoring scheme.
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Applied Computational Genomics - 07 - DNA sequence mapping and alignment | NatokHD