Azstarys for ADHD

Main Chapters: 00:00 Intro – Azstarys for ADHD 00:12 Take home message 01:11 Stimulant Medications for ADHD 04:33 Serdexmethylphenidate (Azstarys) 09:01 Studies on Azstarys 11:06 Conclusion Azstarys is two, or maybe one-and-a-half drugs in one. It contains immediate release (IR) methylphenidate (Ritalin) as well as a prodrug, or inactive form of methylphenidate called serdexmethylphenidate (SDX) which needs to be passed into the intestines before it is cleaved to create an active methylphenidate molecule. While SDX itself has very low potential for addiction, and is therefore classified as a schedule 4 substance, when it is recombined with IR methylphenidate in Azstarys it is a schedule 2 substance, and as such is not an attractive option for individuals who have abused stimulants. Many people who have used Azstarys described it as "smooth" (as do many who have tried another ADHD prodrug, Vyvanse), which is attributed to a very slow tapering of blood levels of methylphenidate, thus avoiding a withdrawal or crash as the drug leaves the body. In fact, the tapering is so gradual with Azstarys because it is actually delivering considerable amounts of methylphenidate throughout the night. From a single morning dose, blood levels of methylphenidate 24 hours later are somewhere between 25% to 40% of the peak blood levels. This would likely cause interference with sleep for many individuals. ----- Free link to my Medium article on Azstarys for ADHD: https://medium.com/invisible-illness/why-some-copycat-drugs-fail-b406ce304367?sk=d6d3dc55486d059797f38e1592915728 Follow https://dockruse.medium.com on Medium for hundreds of full length articles on this subject and more! Access to Full Medium articles requires paid membership. ----- References: Safety and Tolerability of Serdexmethylphenidate/Dexmethylphenidate Capsules in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Month, Open-Label Safety Study (Childress 2023) https://pubmed.ncbi.nlm.nih.gov/36809150/ Serdexmethylphenidate/dexmethylphenidate effects on sleep in children with attention-deficit/hyperactivity disorder (2023, Childress, Mattingly) https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1193455/full Evaluating serdexmethylphenidate and dexmethylphenidate capsules as a once-daily treatment option for ADHD (2023) https://www.tandfonline.com/doi/10.1080/14656566.2023.2218544 Dose Proportionality and Steady-State Pharmacokinetics of Serdexmethylphenidate/Dexmethylphenidate, a Novel Prodrug Combination to Treat Attention-Deficit/Hyperactivity Disorder (2022) https://journals.sagepub.com/doi/10.1089/cap.2022.0015 Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate (2022, Shram) https://www.tandfonline.com/doi/full/10.1080/03007995.2022.2076474#abstract FDA registration of serdexmethylphenidate (2021) https://pubchem.ncbi.nlm.nih.gov/compound/Serdexmethylphenidate#section=Drug-Food-Interactions Full Chapter list: 00:00 Intro – Azstarys for ADHD 00:12 Take home message 01:11 Stimulant Medications for ADHD 02:05 Immediate Release vs Extended Release 03:32 Osmotic Release and Pro Drugs 04:33 Serdexmethylphenidate (Azstarys) 06:03 Studies on Addiction 07:02 Azstarys Formulation 09:01 Studies on Azstarys 10:41 Potential Side Effects of Azstarys 11:06 Conclusion ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world. ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of Politics related videos have an orange background. Dr. Kruse has posted videos in the "Videos", "Live", and "Shorts", sections of this channel. You're welcome to email him with topics you want discussed or people you think he should interview. [email protected] #health #mentalhealth #adhd #azstarys