Associate Professor, Biological Engineering -Bryson Lab
Bryan Bryson: Challenges the reliance on murine models for understanding antimicrobial defense, noting stark species divergences—like humans being itaconate hypomorphs and having different NOS2 regulation compared to mice. To study human-specific responses to intracellular bacteria like M. tuberculosis, the lab developed functionalized beads for proximity labeling to map the phagosome's composition, alongside novel methods for transiently modifying primary human macrophages.
