CHE 118B Final Review Session!

Join my ochem office hours and hang out with me!: https://www.skool.com/bryantochem-inner-circle-5170/about 1. Introduction - 0:00 The session starts with a greeting to participants and a brief overview of the session's topics. 2. Baeyer-Villiger Reaction and Mechanism - 1:05 Explanation of the Baeyer-Villiger oxidation, detailing its mechanism and the migration preferences involved. 3. H+/D+ Exchange - 11:32 Discussion on the process and significance of hydrogen/deuterium exchange in organic molecules. 4. Enone Electrophile (Hard vs. Soft Nucleophile; 1,2-Addition vs. 1,4-Addition/Conjugate Addition) - 15:10 Analysis of electrophilic characteristics of enones and their interactions with hard and soft nucleophiles, including addition patterns. 5. Benzaldehyde with Base Catalyst Gives No Reaction (NR) - Exploration of why reactions involving benzaldehyde and base catalysts fail to proceed. 6. Aldol Condensation (Self, Mixed, and Intramolecular) - 25:55 Overview of various types of aldol condensation reactions, including self, mixed, and intramolecular approaches. 7. Retrosynthetic Analysis on a Bicyclic Product from a Robinson Annulation - 36:13 Detailed retrosynthetic analysis of a bicyclic compound derived from a Robinson annulation. 8. Forward Mechanism for the Robinson Annulation Bicyclic Product - 44:28 Mechanism of the Robinson annulation leading to a bicyclic product, explaining step-by-step transformations. 9. Friedel-Crafts Acylation - 55:32 Discussion on the Friedel-Crafts acylation, highlighting its importance in forming aromatic ketones. 10. The Wittig Reaction - 1:04:59 Comprehensive overview of the Wittig reaction, a key method for forming alkenes from carbonyl compounds. 11. Wittig Reaction Predict the Product 1 - 1:22:45 First predictive problem involving the Wittig reaction, focusing on identifying potential reaction products. 12. Wittig Reaction Predict the Product 2 - 1:24:31 Second predictive exercise for the Wittig reaction, challenging viewers to deduce the outcome. 13. Wittig Reaction Predict the Product 3 - 1:27:22 Third problem in a series testing the ability to predict products from given Wittig reaction setups. 14. Benzene EAS Synthesis Problem - 1:34:02 Complex synthesis problem involving electrophilic aromatic substitution on benzene. 15. Alkene Reactions Synthesis - 1:48:40 Discussion and application of various reactions involving alkenes, focusing on synthetic utility. 16. Chapter 18 Synthesis - 1:50:44 Exploration of synthesis concepts and techniques as outlined in Chapter 18 of the course material. 17. Gamma H is more acidic than Alpha H of an Enone - 1:59:10 Explanation of why the gamma hydrogen in enones is more acidic compared to the alpha hydrogen. 18. Carbonyl + NaH - 2:06:25 Mechanism and outcomes of the reaction between carbonyl compounds and sodium hydride. 19. Organocuprate + Enone Followed Up By Alpha-Protonation or Alpha-Alkylation Reaction - 2:07:47 Detailed discussion on the interaction of organocuprates with enones and subsequent alpha-protonation or alkylation. 20. Challenging, Comprehensive Synthesis Problem - 2:11:33 A complex and comprehensive synthesis problem that integrates multiple reaction mechanisms and strategies. 21. Alpha-Cleavage vs. Beta-Cleavage on Mass Spectrometry - 2:20:39 Comparison of alpha-cleavage and beta-cleavage in mass spectrometry, highlighting how they help in molecular structure elucidation. The Zoom chat transcript can be found through this link: https://www.skool.com/bryantochem-inner-circle-5170/about (Go to the "Classroom" tab; "Spring 2024" Module; "Bryant's Office Hours" Folder; "CHE 118B Final Review Session" Page).