Complementation testing and rescue experiments are widely used techniques in studies of the genetic basis of biochemical pathways.
The work of Adrian Srb and Norman Horowitz described here is a good illustration of both techniques.
This is final video in the series covering the Nobel prize winning work by George Beadle and Edward Tatum.
Part 1: Beadle and Tatum Part 1: Neurospora crassa - https://youtu.be/cETqxjsB_Bw
Part 2: Beadle and Tatum Part 2: The Experiment - https://youtu.be/fXASTY-YoRQ
This video is the product of a collaboration between SciencePrimer and Dr. Kerri Warren, Professor of Biology and Public Health at Roger Williams University.