Cushing’s disease is a serious yet often misunderstood condition caused by a hormone-secreting tumour in the pituitary gland, leading to excess cortisol production. In this video, we break down what Cushing’s disease is, how it differs from other forms of Cushing’s syndrome, and why early diagnosis is crucial. We explore the key signs and symptoms, including weight gain, fatigue, high blood pressure, and mood changes, and walk through the step-by-step process of how doctors diagnose it using specialized hormonal tests and imaging. Viewers will also learn about the main treatment options, including surgery, medication, and radiotherapy, and the importance of long-term follow-up to detect recurrence. Whether you're a medical student, a resident refreshing your knowledge, or someone looking to better understand this complex endocrine disorder, this video offers a clear and accessible overview. Watch, learn, and empower yourself with the essentials of recognizing and managing Cushing’s disease.