Biology Professor (Twitter: @DrWhitneyHolden) describes cytopathic effects (CPE's) observed in cells with various viral infections, giving several examples, including change in shape, loss of surface adherence, shrinking of the nucleus, formation of inclusion bodies or multinucleated syncytia, loss of senescence (immortal cells), and more. Diagnostic uses of CPE's, including pap smears and hepatic steatosis, are also described.