Determining Minimum Effective Polymer Concentration for ASD Using Crystal16

Amorphous Solid Dispersions (ASDs) are one of the widely adopted strategy to enhance the bioavailibility of poorly water-soluble drug candidates. A critical factor in ASD development is identifying the least polymer concentration required to improve solubility and inhibit recrystallization. The webinar will demonstrate how Crystal 16 has been leveraged to determine the minimum polymer concentration required to enhance and sustain supersaturation by ASDs. The methodology offer a quick way to estimate the minimum polymer concentration required within a few hours, which greatly enhance the speed of development.