Exploring different optogenetic systems: Light-induced dimerisation

This video is part of our brand new e-learning course on optogenetics, https://www.embl.de/training/e-learning/optogenetics/index.html. Light-induced dimerisation is the most commonly-used method in non-neuronal optogenetics. When exposed to light of a specific wavelength, a photosensitive protein domain undergoes a conformational change which then causes it to bind to an interaction partner to form dimers or oligomers. This video introduces three prominent dimerisation systems: the cryptochrome, the phytochrome and LOV domain-based iLID systems. Executive producer, stop motion animation & voice over: Richard Grandison Scientific concept & graphic design: Daniel Krueger Video producer & motion graphics: Claudiu Grozea Scientific advisor: Stefano de Renzis