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Molecular Video Lecture 03 (Array CGH)

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Dec 23, 2015
51:38

Topics: Array comparative genomic hybridization (aCGH) 1:25 Copy number variants 1:45 Arrays 2:32 SNP arrays 4:30 Copy number arrays 4:49 Array cost 7:16 Sample comparison 8:20 Genome coverage 12:49 Hybridization 13:57 aCGH vs FISH 15:33 aCGH log2 ratio 16:42 aCGH resolution 16:15 Feature placement on array 18:38 Copy number segmentation/analysis 19:29 aCGH resolution 23:13 aCGH vs FISH 25:04 Disadvantage of aCGH w/ respect to balanced translocations/rearrangements 26:49 Polyploidy on aCGH 30:18 Uniparental disomy (UPD) 31:24 Detecting UPD by aCGH 36:34 SNP detection on Agilent vs Affymetrix arrays 41:28 UPD/LOH analysis by array 42:16 Clinical sensitivity of aCGH 46:24 Clinical utility of aCGH 47:25 aCGH for cancer 49:30 Mosaicism/low level copy changes on aCGH 49:54

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