Multidose Vial Technique

Did you know that many COVID-19 vaccine formulations do not contain preservatives? With some of the new recommendations for booster doses of COVID-19 vaccines, the number of times a vial of COVID-19 vaccine may be accessed will increase significantly. This in-depth video will walk you through all aspects of appropriate sterile technique when accessing COVID-19 vaccine vials, from hand hygiene to selecting a workspace, and drawing up a dose. APhA gratefully acknowledges Moderna’s support of the production of this video. 0:00 - Intro 1:00 - Sterile technique 1:00 - Hand hygiene 1:45 - Select and prepare a workspace 3:03 - Gather needed supplies 3:44 - Sources of contamination 7:56 - Checking the vial 7:56 - Expiration and beyond use dates 9:23 - Inspect vial contents 9:45 - Preparing the vial for use 10:40 - Cleaning the vial stopper 11:52 - Attaching the needle to the syringe 13:18 - Selecting the appropriately sized syringe 15:11 - Drawing up the dose 15:11 - Swirling the vial 16:13 - Entering the vial 17:12 - Rotating entry site in stopper 18:13 - Bevel-up technique 19:12- Draw up 0.25 mL dose 21:35 - Inspect contents of syringe 22:35 - Closing