Check out this open source CircuitPython Game Development platform based on the ARM M4 microcontroller.
/* PewPew M4 Links */
Purchase: https://www.makerfabs.com/circuitpython-pewpew-m4.html
Hackaday: https://hackaday.io/project/165032-pewpew-m4
Assembly: https://pewpew.readthedocs.io/en/latest/pewpew-m4/assembly.html
Github: https://github.com/pewpew-game
/* CircuitPython */
Home: https://circuitpython.org/
stage library: https://learn.adafruit.com/circuitpython-stage-game-library
displayio: https://learn.adafruit.com/circuitpython-display-support-using-displayio/introduction
/* Related */
PewPew Standalone: https://hackaday.io/project/159733-pewpew-standalone
PewPew FeatherWing: https://hackaday.io/project/21578-pewpew-featherwing