physical state I Preformulation studies

physical state is the first significant criteria in pursuing preformulation studies. This section covers various physical properties. Color: It should be Unappealing to the eye and determined by either instrumental methods or visible method that varies from batch to batch. Record of early batches and establishing “specs” is very useful for later production. Coating of body in variable color can be done if found undesirable. Odor and taste: For unpalatable drug use of less soluble chemical form or suppress it by flavors, excipients, coating etc. Drug substances which irritating to skin should be handle with precautions. Flavors, dyes, excipients used will affect stability and bioavailability. Color may be off-white, cream yellow, tan, shiny. Odor may be pungent, sulfurous, fruity, aromatic and odorless. Taste may be acidic, bitter, bland, intense, sweet and tasteless. Bulk characterization studies: It is needed to identify all the solid forms that may exist as a consequence of the synthetic stage such as the presence of polymorphs. Bulks properties such as particle size, bulk density, surface morphology may be changed during the development process and to avoid mislead predictions of solubility and stability which depends on a particular crystalline form. Bulk characterization testing includes: #physicalstate #drvikaspharmacy Our social media links 1. Facebook: https://www.facebook.com/vikas.pandey.399826/ 2. Twitter: https://twitter.com/DrVikasPandey8 3. Research Gate: https://www.researchgate.net/profile/Vikas_Pandey27 For Business queries please email at [email protected]