Progressive Multiple Sclerosis Treatments

1:54 Rituximab (rituxan/truxima) 3:16 Ocrevus 4:09 Siponimod (Mayzent) 5:41 Tysabri 7:10 IV Cladribine 8:15 Methotrexate 9:16 Novantrone (mitoxantrone) 11:09: Biotin 13:38 Ibudilast 14:55 simvastatin (zocor) 16:04 HSCT (hematopoietic stem cell transplant) 17:29: Wahls Protocol 18:30 Comparison of 3-month disability progression data Selected Sources ORATORIO Trial (Ocrevus vs. Placebo in primary progressive multiple sclerosis): https://www.nejm.org/doi/full/10.1056/NEJMoa1606468 Rituxan vs. Placebo in primary progressive MS: https://onlinelibrary.wiley.com/doi/full/10.1002/ana.21867 High doses of biotin in pilot study for chronic progressive multiple sclerosis: http://www.ncbi.nlm.nih.gov/pubmed/25787192 Siponimod Versus Placebo in Secondary Progressive Multiple Sclerosis (EXPAND): https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0140673618304756?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0140673618304756%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F29576505%2F Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis: https://www.nejm.org/doi/full/10.1056/NEJMoa1803583 Pilot Study of HSCT in progressive multiple sclerosis: https://www.nature.com/articles/1700944.pdf Simvastatin reduced brain atrophy in multiple sclerosis (MS-STAT): https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(13)62242-4 The Wahls protocol in progressive MS: https://pubmed.ncbi.nlm.nih.gov/30050380/?from_term=terry+wahls&from_sort=date&from_filter=simsearch3.fft&from_pos=7 The Wahls protocol in progressive MS for fatigue: https://pubmed.ncbi.nlm.nih.gov/31211794/?from_term=terry+wahls&from_sort=date&from_filter=simsearch3.fft&from_pos=3 Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! My book "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter: https://twitter.com/Brandon_Beaber Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: https://youtu.be/wy9FL1-jup4 T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.