Remove Wrinkles

Like what you hear? Don’t forget to subscribe and leave a 5-star review! - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - SHOP: https://store.rajanimd.com/ USE Coupon Code SKIN10 for 10% Off. These are the EXACT Products Dr Rajani uses for himself and his patients. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - FREE TIP: https://store.rajanimd.com/signup Want a tip each week? Click above to join my newsletter. - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ASK ME: https://store.rajanimd.com/suggest Suggest a topic or ask a question for me to answer on the show! - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - LEARN: https://store.rajanimd.com/school Free courses and how to tutorials - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Testosterone cream on the face is having a comeback because of a very old-school idea: decades ago, researchers actually tested topical testosterone propionate on aging skin, including the face, and reported modest visible smoothing in some cases with more noticeable changes seen under the microscope/biopsy. In this video, I break down what that older work really suggests, why the type matters (short-acting propionate vs modern systemic gels), and what the realistic trade-offs are. Testosterone can push skin in a “more androgenic” direction, so oily skin, acne flares, and unwanted hair are always on the menu for the wrong person or the wrong formula. I also show the systemic biopsy data people love to reference (postmenopausal women on oestrogen + testosterone implants showing higher skin collagen content), and explain why that’s interesting science but not the same thing as proving a face lift in a jar. Finally, we talk safety and why I’m cautious about rub-off testosterone gels (partner/child transfer is documented in the medical literature). Educational only. This is not personal medical advice. If you’re considering anything hormone-based, do it with a clinician who understands dosing, formulation, and risk screening. ---------------------------------------------------------------------------------------------------------------- STUDIES: Topical testosterone propionate on aging skin (classic 1960s-era paper) Papa CM. Effect of topical hormones on aging human skin. Journal of the Society of Cosmetic Chemists. 1967;18:549–562. Key point: clinically visible changes (wrinkle “effacement,” etc.) were modest, while microscopic/biopsy architecture changes were more impressive. PDF: Estrogen + testosterone implants and skin collagen (the “48% greater” biopsy signal) Brincat M, Moniz CF, Studd JWW, et al. Sex hormones and skin collagen content in postmenopausal women. Br Med J (Clin Res Ed). 1983. (PubMed: 6416400) Key point: skin collagen content (via hydroxyproline from biopsies) was reported ~48% higher in women treated long-term with oestrogen + testosterone implants vs matched untreated controls. Type III collagen shift with estradiol + testosterone implants Savvas M, et al. Type III collagen content in the skin of postmenopausal women receiving oestradiol and testosterone implants. BJOG. 1993. (PubMed: 8476808) Key point: HRT with estradiol + testosterone implants was associated with an increase in the proportion of type III collagen in skin. Testosterone gel transfer risk (why you don’t want “rub-off” products for this conversation) Patel A, et al. Prenatal virilization associated with paternal testosterone gel exposure. (Case report) 2010. Key point: documents clinically meaningful secondary exposure from transdermal testosterone gel via skin contact/transfer. ---------------------------------------------------------------------- FTC: Some links included in this description might be affiliate links. If you purchase a product through one of them, I will receive a commission (at no additional cost to you). I truly appreciate your support of my channel. Thank you for watching! Video is not sponsored. DISCLAIMER: This video does not contain any medical or health related diagnosis or treatment advice. Content provided on this YouTube Channel is for informational purposes only. For any medical or health related advice, please consult with a physician or other healthcare professionals. Further, information about specific products or treatments within this video are not to diagnose, treat, cure or prevent disease. --------------------------------------------------------------------------- 00:00 Testosterone for glow + why the aging curve is predictable 01:20 Why women look at testosterone (and what it actually is) 04:33 The “biopsy proof” systemic data (collagen signal) 06:37 Face-only idea: why the type matters (propionate vs gels) 07:42 The 1960s topical testosterone propionate study (what it showed) 10:14 Trade-offs, who it fits, compounding, and safety takeaways