X RAD SmART: Plan SmART

Advancing our understanding of the molecular biology of cancer requires more precise tools to study the radiation-induced effects used in translational research. Five years ago, Precision X-Ray introduced the X-RAD 225Cx, which showed that combining 3D volumetric imaging with highly accurate specimen positioning allowed for precise, conformal image-guided radiation therapy to specific targets in mice, rats and rabbits. The X-RAD SmART, the next generation of cabinet IGRT systems, takes this to a new level of precision. The X-RAD SmART takes the already excellent design of the X-RAD 225Cx, and improves it in every way imaginable. The redesigned cabinet still provides complete shielding from all internal x-rays, while moving to a more flexible design, allowing for installations in just about any laboratory space. The new cabinet design is not just about increased efficiency, however, as it also has higher precision electromechanics under the hood, allowing for even better targeting accuracy. Superior hardware, however, cannot be fully taken advantage of without superior software. Pilot, developed by the esteemed scientific team at Princess Margaret Cancer Center, is a fully functional suite of tools used to acquire images, deliver therapy, guide the targeting system and control system calibrations. SmART Plan, developed at Maastro Clinic, combines a user friendly interface with state-of-the-art Monte Carlo calculation algorithms to rapidly devise treatment plans with gold standard accuracy for static beams, arcs, and even non-coplanar treatments across single and multiple isocenters. This enables rapid, accurate treatments to be delivered in any scenario, ranging from simple subcutaneous xenografts all the way to complex metastatic models. However, the system is not limited to CT guidance alone. The X-RAD SmART is the ONLY system with a fully integrated Bioluminescence Imaging Platform. Because the system is fully integrated, registration with CT is fully automated, allowing for precise tumor localization for non-palpable tumors. The system can also serve to measure tumor viability across studies. As well, Co-Pilot, developed by the Netherlands Cancer Institute can automatically register DICOM images from other available platforms, effectively providing multi-modality image-guidance. These features, combined with PXI’s legendary service, make the X-RAD SmART the clear choice in small animal precision radiotherapy