Alpha-Keto Halogenation

I set up an alpha-keto halogenation reaction. In this transformation, I wanted to insert a bromine atom next to a ketone. Into a pressure tube charged with a magnetic stir bar and the ketone, I added the solvent and switched on the stirring. After that, I added catalytic amounts of para-toluenesulfonic acid, and the pale yellow color of the reaction mixture immediately faded. Then, I also added one equivalent of NBS before sealing the tube. With all the reagents in place, I transferred the sealed tube into a preheated oil bath at around 85 C. Disclaimer: All chemical reactions demonstrated in this video are performed by trained professionals in a controlled laboratory environment. Do not attempt to replicate these experiments without appropriate training and supervision. Always use personal protective equipment (PPE) including lab coats, safety goggles, and gloves when handling chemicals. Be aware of the specific hazards associated with each chemical used, such as toxicity, flammability, and reactivity. For detailed information on each chemical refer to Material Safety Data Sheets (MSDS) or Safety Data Sheets (SDS). The creators of this video are not responsible for any harm or injury resulting from the misuse of the information provided. This video is for educational purposes only.